The Powerpuff Girls Movie

The Powerpuff Girls Movie is a 2002 American animated superhero actionadventure comedy film based on the Cartoon Network animated television series of the same name. Produced by Cartoon Network Studios for Warner Bros. Pictures and Cartoon Network, the film debuted in the United States on July 3, 2002. It is a prequel to the series, telling the origin story of how the Powerpuff Girls were created and how they came to be the defenders of Townsville. It is the first theatrically released Cartoon Network film.

Professor Utonium hopes that he will create three perfect little girls, using a mixture of sugar, spice and everything nice to improve Townsville, a fictional city plagued by crime. He is shoved by his laboratory assistant and a destructive chimpanzee named Jojo, but he accidentally breaks a flask of a mysterious substance called Chemical X that spills into the mixture and explodes in Jojos face. The Professor realizes that the experiment is successful, having produced three little girls, whom he names Blossom the smart and mature one, Bubbles the cute and bubbly one and Buttercup the rough and tough one. They also have superpowers as a result of the additional Chemical X, though they all immediately grow to love each other as a family.During their first day of school, the girls learn about the game tag and begin to play amongst themselves, which quickly grows destructive every time they use their powers. They take their game downtown, accidentally causing massive damage to the city until the Professor calms them down and cautions them against using their powers outside. As a result of the destruction, the citizens of Townsville treat the girls as outcasts and arrest the Professor for creating the girls. The despondent girls try to make their way home on foot, but become lost in an alleyway and were ambushed by the Gangreen Gang. They are rescued by Jojo, whose brain has mutated and given him superintelligence as a result of the Chemical X explosion. ........

Source: Wikipedia